Computational and theoretical models of brain dynamics

A main overarching theme of most of the work we do in the WBMG is meso/macroscopic computational models of neural dynamics. We use mathematical models describing neural population activity on the scale of millimetres to centimetres, together with network structure from macaque histology or diffusion MRI fibre tracking, to simulate (approximately) whole-brain activity measurements of the kind measured by fMRI and M/EEG. These techniques are gradually allowing us to obtain more mechanistic insights into observed patterns in neuroimaging data relating to the resting state, oscillations, and the impact of neurological and neurodegenerative disease.