Damage to the brain from stroke, injury or neurological disease disrupts not only the tissue directly affected but also the wider networks it connects to. We study how focal lesions alter large-scale brain structure and dynamics, for example how secondary thalamic degeneration after stroke produces the abnormal slowing seen in the EEG, and how these changes relate to cognitive and language impairments. Using connectome-based models, we aim to predict the network consequences of a given pattern of damage, and to inform clinical interventions such as neurosurgical planning and stimulation-based rehabilitation.
