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Whole Brain Modelling


In the Whole Brain Modelling Group (aka GriffLab) at the Krembil Centre for Neuroinformatics (KCNI), we take a “bird’s-eye” approach to understanding brain organization and how it is affected in neuropsychiatric and neurological disease.

We work extensively with structural and functional neuroimaging data (sMRI, fMRI, DWI, MEG, EEG), employing the latest cutting-edge analysis methods to study connectivity, oscillations, and their modification by brain stimulation and drugs. This information is used to construct and constrain computational models of brain dynamics that combine meso-scale mathematical descriptions of neural population activity with whole-brain network structure. The meso-scale approach strikes a balance between granularity (level of physiological detail) and coverage (number of brain regions included), that is well-matched to the type of information that can be obtained from modern in-vivo neuroimaging techniques. Together with colleagues in the KCNI microcircuit modelling and computational genomics groups, we are also developing multi-scale modelling approaches that bridge cellular-level and population-level descriptions of neural activity.

Our long-term goal is the development simultaneously detailed and holistic in-silico computational and theoretical accounts of brain function, cognition, and their pathologies.

News and Musings

Brainhack CAN Toronto

BIDS-Compmodels worshop - Princeton

Exciting times.

Research

We have a number of ongoing research projects in the areas of computational neuroscience, neuroimaging, and neuroinformatics. Click the links below for details.

Selected Publications

More publications here

A theoretical study on the phenomenon of persistent entrainment using a mean-field model of recurrent delayed inhibition

Talks & Teaching

A selection of slides, videos, and code from recent talks and tutorial workshops on a variety of topics.

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Using human connectome project (HCP) data

Tutorial session given at Rotman Research Institute, Baycrest (jointly given with Dr. Erin Dickie)

The spherical harmonic structure of the human connectome

Invited talk at the ‘Large scale trends in cortical organization’ workshop, Leipzig

Modelling brain dynamics at rest: practical tools and theoretical perspectives

Guest (inaugral) lecture given for the Krembil Computational Neuroscience (KCN) Events series

First of the two lectures given at the Banff International Research Station (BIRS) workshop on Topological Methods in Brain Network Analysis

Second of the two lectures given at the Banff International Research Station (BIRS) workshop on Topological Methods in Brain Network Analysis

Analysis of fMRI data: principles & techniques

Lecture given by JG at the Canadian Association for Neuroscience Meeting Satellite workshop: Neural signal and image processing: quantitative analysis of neural activity

Introduction to diffusion-weighted MRI

Workshop given by JG at Rotman Research Institute

Podcast & blog on neuroscience type matters with esteemed friend and colleague Dr. Christopher Harris of NIH and Backyard Brains.

Code & Software

Pointers to various code and software tools that we have either developed ourselves, or use extensively. Non-exhaustive list!

Contact

  • john.griffiths@camh.ca
  • 416-535-8501 x 30251
  • Krembil Centre for Neuroinformatics (KCNI); Centre for Addiction and Mental Health (CAMH): 250 College Street (Floor 12), Toronto ON